Meta-analysis: melatonin for the treatment of primary sleep disorders
Melatonin shortens the time it takes to fall asleep, increases total sleep duration, and improves sleep quality. The effect is mild but remains even with longer-term use, and thanks to its low risk of side effects, it may be a suitable option for treating insomnia.
University of São Paulo Medical School, São Paulo, Brazil
Link to the study
Prolonged-release melatonin for insomnia
Melatonin helps improve sleep quality in people with insomnia aged 20–80, even with long-term use (6 to 12 months), without the body building tolerance to it or sleep problems occurring after discontinuation.
The Clinique Lyon-Lumière, Meyzieu, France
Link to the study
Long-Term Melatonin Therapy for Adolescents and Young Adults with Chronic Sleep Onset Insomnia and Late Melatonin Onset
Long-term use of melatonin in children with chronic difficulties falling asleep appears to be completely safe.
Faculty of Veterinary Medicine, Pharmacy Department, Utrecht University, Utrecht, The Netherlands
Link to the study
Evaluation of sleep, puberty and mental health in children with long-term melatonin treatment
Long-term melatonin use in children has no negative effect on sleep quality, mental health, or pubertal development compared to other children of the same age.
Faculty of Veterinary Medicine, Pharmacy Department, Utrecht University, Utrecht, The Netherlands
Link to the study
The amplitude of endogenous melatonin production is not affected by melatonin treatment
Taking melatonin does not change the total amount of melatonin your body produces on its own.
Department of Psychiatry and Neurology, Asahikawa Medical College, Japan
Link to the study
Impact of Low-Dose Melatonin Supplementation on Testosterone Levels
Low doses of melatonin in adult men were not associated with a decrease in testosterone levels.
Desai Sethi Urological Institute, Miller School of Medicine, University of Miami
Link to the study
Effect of melatonin supplementation on sleep quality
Melatonin supplementation has positive effects on sleep quality in adults with respiratory diseases, metabolic disorders, and sleep disorders.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical, Tehran, Iran
Melatonin ingestion after exhaustive late-evening exercise improves sleep quality and quantity
A single dose of melatonin after an intense evening workout improved sleep quality and duration in young athletes, reduced fatigue and muscle soreness, and improved some physical and cognitive performance measures the following morning.
High Institute of Sport and Physical Education, Manouba University, Manouba, Tunisia
Link to the study
Medications for Sleep Schedule Adjustments in Athletes
Melatonin can help athletes manage their sleep schedule more effectively, improve sleep, and thereby support performance in competitions.
Greenville Health System–University of South Carolina Greenville School of Medicine, Greenville, South Carolina, USA
Link to the study
Exercise-induced oxidative stress and melatonin supplementation
Melatonin has antioxidant and anti-inflammatory effects and may help protect athletes’ muscles from damage caused by intense training.
Faculty of Physical Culture and Health, University of Szczecin, Szczecin, Poland
Link to the study
Impact of Melatonin Supplementation on Sports Performance and Circulating Biomarkers
Melatonin may help elite athletes reduce inflammation, protect the liver and muscles from damage, and positively influence certain blood markers.
Department of Chemistry, Polytechnic Secondary Education High School, Soria, Spain
Link to the study
The Effects of Melatonin Supplementation on Professional Football Player Performance
In professional football players, melatonin helps reduce inflammation and muscle damage after intense exertion. A direct effect on performance improvement has not yet been proven, but due to its positive effects on recovery, it could be useful for athletes.
Health Science and Nutrition Research, Department of Nutrition and Food Science, University of Granada, Spain
Link to the study
Melatonin for the prevention and treatment of jet lag
Melatonin helps with overcoming jet lag.
UK Cochrane Centre, 9 Park Crescent, London, UK
Link to the study
